Box 1:
The conditional access policy must be applied or assigned to Users and Groups.
Box 2:
The conditional access policy must be applied when users access the Azure portal, which is a cloud app. That is: Microsoft Azure Management
Box 3:
Access control must require multi-factor authentication when granting access.
Reference:
https://docs.microsoft.com/en-us/azure/active-directory/conditional-access/app-based-mfa